Efficacy of a novel in ovo-attenuated live vaccine and …
WEBSep 15, 2021 · In this study, we focused on the protective efficacy of a novel in ovo-attenuated live IBDV vaccine (IBD-CA) consisting of IBDV-infected cells, and an rHVT-IBD vaccine, against virulent IBDV in 7, 9, 11, and 18 days old SPF chicks after in ovo vaccination. The IBD-CA vaccine showed higher protective efficacy than rHVT-IBD at earlier ages in ...
Efficacy of live attenuated, vector and immune complex infectious ...
WEBSep 12, 2022 · The present study aims to investigate, in field conditions, the efficacy of these approaches in preventing IBDV infection in laying chickens vaccinated with either live attenuated, vector or immune complex (icx) vaccines.
Frontiers | Efficacy of live attenuated, vector and immune …
WEBSep 11, 2022 · The present study aims to investigate, in field conditions, the efficacy of these approaches in preventing IBDV infection in laying chickens vaccinated with either live attenuated, vector or immune complex (icx) vaccines.
Comparison of two attenuated infectious bursal disease vaccine …
WEBJan 11, 2021 · Live attenuated vaccines, which are the most prevalently used IBD vaccines in the field, can be categorized into three groups: Mild, intermediate, and intermediate-plus or hot vaccines . The viruses in mild vaccines exhibit poor efficacy in the presence of certain levels of maternally derived antibodies (MDAs) [ 13 ] …
Comparative Evaluation of HVT-IBD Vector, Immune Complex, and Live …
WEBFeb 26, 2019 · The best results were obtained when using the vector IBD vaccine followed by the immune-complex vaccine, and the use of killed along with the live intermediate vaccine in terms of mortality, feed conversion ratio, bursal and spleen index, bursal lesion score, and serology.
Generation of a novel attenuated IBDV vaccine strain by …
WEBJun 29, 2024 · To evaluate the protective efficacy of IBDV-VP5/3m as a potential attenuated live vaccine against parental IBDV-WT infection, we challenged the previously immunized chickens with IBDV-WT strain at a dose of 10 6 TCID 50 /100 μL (tenfold higher than the primary immunization with IBDV-VP5/3m) 29 days after the primary immunization.
Reverse genetics approaches for live-attenuated vaccine
WEBTo date, vaccination with live-attenuated vaccine (LAV) is a convenient method to provide effective protection against IBDV infection. Classical attenuated viruses are usually obtained by either passaging virus in cultured cells or natural isolation.
Generation of a novel attenuated IBDV vaccine strain by …
WEBJun 29, 2024 · Infectious bursal disease virus (IBDV) is an acute and highly infectious RNA virus known for its immunosuppressive capabilities, chiefly inflicting rapid damage to the bursa of Fabricius (BF) of chickens. Current …
Blood B Cell Depletion Reflects Immunosuppression Induced by Live ...
WEBApr 25, 2022 · IBDV infections are mostly controlled by using live-attenuated vaccines. Live-attenuated Infectious Bursal Disease (IBD) vaccine candidates are classified as "mild," "intermediate," "intermediate-plus" or "hot" based on their residual immunosuppressive properties.
The attenuated live vaccine strain W2512 provides protection …
WEBJul 4, 2023 · This study highlights the protective effect of commercial attenuated live vaccines against the novel IBDV variant and provides guidance for the prevention and control of this disease.