Comparison of the immunogenicity and protective efficacy of
WEBMar 27, 2024 · The mpox virus that drove the 2022–2023 outbreak was genetically and clinically different from prior mpox outbreaks and was characterized by transmission from close contacts in MSM populations and potentially through sexual intercourse, which distinguished it from previous mpox outbreaks (3, 11).
Comparison of protection against mpox following mRNA or …
WEBSep 4, 2024 · An mRNA vaccine was designed against Orthopoxviruses (including mpox and smallpox) and compared with current standard of care modified vaccinia Ankara (MVA) vaccines in a nonhuman primate model of lethal mpox virus infection. In-depth immunological profiling revealed a critical role for Fab and Fc functions against aspects of poxvirus disease and provided broad pan-Orthopoxvirus immunity.
A multivalent mRNA monkeypox virus vaccine (BNT166 ... - Cell Press
WEBMar 14, 2024 · In response to the 2022 outbreak of mpox driven by unprecedented human-to-human monkeypox virus (MPXV) transmission, we designed BNT166, aiming to create a highly immunogenic, safe, accessible, and scalable next-generation vaccine against MPXV and related orthopoxviruses.
Multi-omics characterization of the monkeypox virus infection
WEBAug 8, 2024 · Monkeypox (mpox) virus (MPXV) is a pathogenic orthopoxvirus and etiological agent of the zoonosis mpox, first identified in 1970 1.
Mpox virus infection and drug treatment modelled in human skin …
WEBOct 12, 2023 · Mpox virus (MPXV) primarily infects human skin to cause lesions. Currently, robust models that recapitulate skin infection by MPXV are lacking. Here we demonstrate that human induced...
Mpox (formerly monkeypox): pathogenesis, prevention and …
WEBDec 27, 2023 · Mpox (formerly monkeypox) is an emerging zoonotic disease caused by Mpox virus infection, which affects both humans and animals. 1,2 The virus was first discovered in monkeys in 1958 and has...
Polyvalent mpox mRNA vaccines elicit robust immune responses …
WEBIn this study, we construct two bivalent MPXV mRNA vaccines, designated LBA (B6R-A29L) and LAM (A35R-M1R), and a quadrivalent mRNA vaccine, LBAAM (B6R-A35R-A29L-M1R). The immunogenicity and protective efficacy of these vaccines alone or in combination were evaluated in a lethal mouse model.
Insights into the Transmission, Host Range, Genomics, Vaccination, …
WEBMay 28, 2024 · This review delves into the historical context, current epidemiological landscape, genomics, and pathobiology of monkeypox virus (MPXV). Furthermore, it elucidates the present vaccination status and strategies to curb the spread of monkeypox. Monkeypox, caused by the Orthopoxvirus known as MPXV, is a zoonotic ailment.
Immunogenic proteins and potential delivery platforms for mpox …
WEBAug 1, 2023 · Membrane and envelope proteins located in the outer layer of virion are essential for virion attachment to host cells. Hence, these proteins can potentially serve as attractive targets for developing MPXV-specific vaccine candidates.
Immunogenic proteins and potential delivery platforms for mpox …
WEBJun 23, 2023 · Monkeypox (mpox) is a self-limiting disease with clinical symptoms including fever, headache, lymphadenopathy, and myalgia [1]. Viral culture, electron microscopy, immunohistochemistry, serum IgG and IgM assays, and PCR techniques are several methods for the diagnosis of MPXV [2].
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