Animal models of mpox virus infection and disease - PMC
WEBJun 4, 2023 · MPXV infections in various animal models have provided a central platform for identification and comparison of disease pathogenesis between contemporary and historic isolates. In this Review, we discuss the susceptibility of various animals to MPXV, and describe the key pathologic features of infection models.
Multi-omics characterization of the monkeypox virus infection
WEBAug 8, 2024 · Roland Rad, Andrew G. Bowie, Ulrike Protzer & Andreas Pichlmair. Nature Communications 15, Article number: 6778 (2024) Cite this article. 2920 Accesses. 7 Altmetric. Metrics. Multiple omics...
Animal models of mpox virus infection and disease - PubMed
WEBJun 4, 2023 · In this review, we discuss the susceptibility of various animals to MPXV, and describe the key pathologic features of rodent, rabbit and nonhuman primate models. We also provide application examples of animal models in elucidating viral pathogenesis and evaluating effectiveness of vaccine and antiviral drugs.
Understanding the biology of monkeypox virus to prevent future ...
WEBMay 9, 2024 · Pox virus. Viral infection. Abstract. Historically, monkeypox (mpox) was a zoonotic disease endemic in Africa. However, in 2022, a global outbreak occurred following a substantial increase in...
Mpox (formerly monkeypox): pathogenesis, prevention and …
WEBDec 27, 2023 · 10 Citations. 89 Altmetric. Metrics. Abstract. In 2022, a global outbreak of Mpox (formerly monkeypox) occurred in various countries across Europe and America and rapidly spread to more than...
Mpox Virus: Its Molecular Evolution and Potential Impact on Viral ...
WEBApr 18, 2023 · Mpox (previously known as monkeypox) is an infectious viral illness caused by the mpox virus (MPXV), an orthopoxvirus that belongs to the family Poxviridae. The symptoms of mpox in humans are similar to those of …
Virulence differences of mpox (monkeypox) virus clades I, IIa, and …
WEBFeb 21, 2023 · We demonstrate that the wild-derived inbred castaneous mouse provides an exceptional animal model for investigating clade differences in mpox virus virulence and show that the order is clade I > clade IIa > clade IIb.1.
NIH Scientists Develop Mouse Model to Study Mpox Virulence
WEBFeb 14, 2023 · They developed a mouse model of the disease and used it to demonstrate clear differences in virulence among the major genetic groups (clades) of mpox virus (MPXV).
Virulence differences of mpox (monkeypox) virus clades I, IIa, and …
WEBFeb 2, 2023 · We demonstrate that the wild-derived inbred castaneous mouse provides an exceptional animal model for investigating clade differences in mpox virus virulence and show that the order is clade I > clade IIa > clade IIb.1.
(PDF) Animal models of mpox virus infection and disease
WEBJun 1, 2023 · Mpox (monkeypox) virus (MPXV), which causes a mild smallpox-like disease, has been endemic in Africa for several decades, with sporadic cases occurring in other parts of the world.