Selectivity of NSAIDs is currently based on an IC 50 value (the concentration at which an NSAID produces 50% inhibition of COX-1 and/ or COX-2). IC 50 values provide no indication of the ...
Researchers warn that this finding does not imply that cancer patients can take aspirin without a medical prescription.
Cox-2 inhibitors are a newer form of prescription NSAID. As you might guess, they only affect Cox-2 enzymes and not Cox-1. Two of them -- Bextra and Vioxx -- are no longer sold because of concerns ...
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The Ibuprofen Alternative That's Better For Your Stomach (But You Need A Prescription For It)That's because most NSAIDs, like ibuprofen, are COX-1 inhibitors, which block prostaglandins that produce inflammation. However, prostaglandins also protect your stomach lining (per the National ...
Although the effects of anti-inflammatory drugs have been well studied, little is known about the signaling pathways involved in the inflammatory response. The recent finding that cyclopentenone ...
All NSAIDs variably inhibit COX-1 and COX-2 and the mechanisms of inhibition fall into three broad categories, although there are exceptions. For example, nimesulide is a weak competitive ...
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