Herpesviruses are responsible for both substantial human suffering and economic loss. Most members of this class of virus can cause either a lytic or latent infection in host cells. A lytic infection ...

[7] In addition to the productive, lytic replication that generates infectious viral progeny, herpesviruses also establish latent infections where few, if any, viral proteins are expressed and no ...

Bioinformatics revealed two putative granzyme B cleavage sites in HSV-1 immediate early protein ICP4, which is required to switch transcription from latent to lytic genes. In a proteolysis assay ...