In summary, multiple lines of pre-clinical evidence support a therapeutic role for PDE5 inhibition with sildenafil in the management of heart failure patients. However, human trials to date are ...

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Mirodenafil was generally well tolerated, and the authors note that the efficacy of mirodenafil is comparable to other PDE5 inhibitors currently available or under trial.

Based on the results of this trial, the FDA-recommended dose for treatment of PAH is 40 mg daily. While not numerous, more pharmacogenetic studies exist in PDE5 inhibitors than in other PH ...

After further trials, sildenafil citrate was approved by ... Sildenafil falls into a class of drugs called PDE5 inhibitors, along with other drugs like Cialis (tadalafil), Stendra (avanafil ...