Recent advances in molecular antibody biology and structural protein engineering enabled the modification of IgG antibodies to enhance their therapeutic potential. This review summarizes recent ...
Nevertheless, FUT8-related depletion of core fucosylation has been linked to antibody dysfunction, profound alterations in B and T cells, hypogammaglobulinemia, as well as impaired recognition, ...
Interestingly, we additionally noted a higher degree of ACPA-IgG1 Fc core fucosylation at baseline as compared with total IgG1, which further increased prior to diagnosis. Conclusions ACPA display ...
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