J&J sells macitentan on its own as Opsumit, currently a top-selling drug for PAH with sales of $2 billion a year, and also makes $1.6 billion from prostacyclin analogue Uptravi (selexipag).

The vascular endothelium plays a critical part in maintaining blood fluidity and vascular smooth muscle tone through (a) prostacyclin, a potent vasodilator ...

Table 1. Suggested strategies for analgesic/anti-inflammatory treatment and cardiovascular prevention among patients with inflammatory disease and different levels of risk of vascular events ...

Meloxicam is an enolcarboxamide with preferential COX-2 inhibitory activity. In vitro studies with human tissues have confirmed the high affinity of meloxicam for COX-2, whereas COX-1 was ...