Here, the authors develop a high-fidelity RNA-targeting CRISPR system to suppress the repeat RNA expressed from the C9ORF72 gene, which improved abnormalities in a mouse model. CRISPR-CasRx ...

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized by the deterioration of motor neurons. However, this complex disease extends beyond the boundaries of the central ...

Motor neuron diseases (MNDs) comprise a large and heterogeneous ... The incidence of MNDs varies in different populations; however, the most prevalent, Amyotrophic Lateral Sclerosis, is estimated to ...

tmd.ac.jp Progressive accumulation of specific misfolded protein is a defining feature of amyotrophic lateral sclerosis (ALS), similarly seen in Alzheimer disease, Parkinson disease ... spread through ...

The pathological cascade leading to the fatal adult neurodegenerative disorder amyotrophic lateral sclerosis (ALS) is not yet clear ... be a final trigger in an ‘ALS-primed’ system. Production of the ...

Trouble sleeping is common in other neurodegenerative diseases, but past research has only suggested that it occurs in patients with amyotrophic lateral sclerosis. Now, a new study has not only ...

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease that remains incurable, despite decades of basic and clinical research. Key stakeholders—including the US National ...

J&J buys Intra-Cellular in $14.6 billion deal, delving further into central nervous system disorders FILE - The Johnson & Johnson headquarters in New Brunswick, New Jersey, on Feb. 8, 2024.

In 2022, more than 941,600 Americans died from cardiovascular disease. Heart disease remains the leading cause of death in the United States, according to a new report. The American Heart ...

The sensation of being detached from your surroundings may point to a hard-to-diagnose condition. By Christina Caron Barrie Miskin was newly pregnant when she noticed her appearance was changing.

Jan. 15, 2025 — New observational data and simulation models have confirmed a new type of planet unlike anything found in the Solar System. This provides another piece of the puzzle to ...