GLENDALE -- San Francisco 49ers RB Isaac Guerendo was carted off the field in Week 18's matchup against the Arizona Cardinals. He has already been ruled out with a knee and ankle injury. On just the ...

Finally, the 2024 nightmare season for the San Francisco 49ers is over with. It ends in a blowout 47-24 loss to the Arizona ...

The Arizona Cardinals and San Francisco 49ers are locked into a Week 18 battle in their finale at State Farm Stadium later today. For one last time, you'll be able to place some cold hard cash on the ...

San Francisco 49ers quarterback Brock Purdy is dealing with a nerve issue in his elbow, and he is not expected to play in Week 18 against the Arizona Cardinals.

ESPN Analyst Ryan Clark says he believes Baltimore Ravens quarterback Lamar Jackson is the best player in the NFL and thinks ...

The 49ers are about to be in an extremely intriguing situation in 2025. No, I’m not talking about a big Brock Purdy extension or free agency, ...

The 49ers don't have one clear need entering this year's draft. They have needs everywhere. They're 6-10 entering the final game of the season.

Backup quarterback Joshua Dobbs will make his debut start for the 49ers in their regular-season finale against the ...

The Los Angeles Rams would be at a major advantage if they were to draw Washington as their first playoff opponent ...

Brock Purdy may have cost himself some serious money this season. He wasn't bad, but he wasn't good, either. He was remarkably mediocre.

The 49ers flipped Lance to the Cowboys in exchange for a fourth-round pick before the 2023 season. He has appeared in three games for Dallas this season, playing a total of 20 snaps and throwing for ...

The final injury report for both the Arizona Cardinals and San Francisco 49ers just dropped, and the two sides could be without some star power in the season fi ...