After inversion by CRISPR/Cas, the epigenetic state of plant chromosomes remains stable
The epigenetic state of chromatin, gene activity, and chromosomal positions are interrelated. A research team from the IPK ...
Scientists create new register with thousands of entangled nuclei to scale quantum networks
In an advance for quantum technologies, researchers at the Cavendish Laboratory, University of Cambridge, have created a ...
How NAD Keeps Your Cells Energized and Slows Down Aging
NAD, a vital molecule for cellular energy and DNA repair, plays a central role in aging and diseases like cancer and ...
C&EN16d
SMAP3-ID for Identification of Endogenous Protein–Protein Interactions Reveals Regulation of Mitochondrial Activity by Lamins
Program in Chemical Biology, Department of Chemical Physiology and Biochemistry, Oregon Health & Science University, 3181 SW Sam Jackson Park Rd, Portland, Oregon 97239, United States ...
eLife17d
Robust single nucleus RNA sequencing reveals depot-specific cell population dynamics in adipose tissue remodeling during obesity
Single nucleus RNA sequencing (snRNA-seq), an alternative to single cell RNA sequencing (scRNA-seq), encounters technical challenges in obtaining high-quality nuclei and RNA, persistently hindering ...
Scientific American27d
Jumping ‘Numts’ from Mitochondria Can Be Fast and Deadly
And our chromosomes, although safely ensconced within the cell’s nucleus, are far from stable. A piece of genetic code from another chromosome, or even from a virus, can embed itself into the ...
Frontiers1y
Mesenchymal stem cell-derived secretome enhances nucleus pulposus cell metabolism and modulates extracellular matrix gene expression in vitro
In this study, we aimed to evaluate the effect of bone-marrow-MSCs (BM-MSCs) and adipose-derived stromal cells (ADSCs) secretomes on human nucleus pulposus cells (hNPCs) in vitro. Methods: BM-MSCs and ...
Frontiers3y
Single Nucleus RNA Sequence (snRNAseq) Analysis of the Spectrum of Trophoblast Lineages Generated From Human Pluripotent Stem Cells in vitro
Libraries were pooled and sequenced on an Illumina NovaSeq S1 flow cell with a goal to generate 50,000 reads per nucleus with a sequencing configuration of 28 base pair (bp) on read1 and 91 bp on read ...