Nikki Glaser opened the 82nd Golden Globes by welcoming the packed room of celebrities to “Ozempic’s biggest night.” And as promised, the stand-up comedian got in a self-deprecating joke up top by saying that she was excited to be in a room full of producers at the Beverly Hilton with “all of my clothes” on.

Nikki Glaser made history at the 2025 Golden Globes. The comedian was the first woman to host the award show solo — and she came prepared for her opening monologue. She revealed on the red carpet she had rehearsed the nine-minute opening 93 times.

One of the questions going into this year’s Golden Globes Awards was: Could first-time host Nikki Glaser match her career-making performance on last May’s Tom Brady Comedy Central roast? The short answer: Yes.