Although differentiation and activity of bone-forming osteoblasts are regulated at various levels, there is ample evidence ...

In the past few years, a fascinating new role for osteoclasts has been unveiled in promoting bone formation and facilitating osteoblast migration to the remodeling sites through a number of different ...

Indeed, the pathophysiology of bone lesions in osteogenesis imperfecta remains unknown. Osteogenesis imperfecta is a disease of the osteoblast. The osteoblast produces an abnormal matrix that does not ...

Research on the pathways from biophysical stimulation of osteoblast to osteoblast synthetic activity via involvement of mitochondrial machinery might reveal a new aspect of bone regeneration ...

We have previously shown that Fra-2 controls bone development, osteoclast size [1] and osteoblast differentiation through direct regulation of Collagen 1a2 and Osteocalcin (Ocn) [2]. Recent studies ...

A new review was published in Oncotarget's Volume 15 on August 2, 2024, entitled, “Targeting WNT5B and WNT10B in osteosarcoma ...

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Despite extensive studies showing the function of mitogen-activated protein kinases (MAPKs) in osteoblast differentiation, none of these studies show in vivo evidence of a role for MAPKs in osteoblast ...

Financial writer rates Mereo BioPharma stock as Hold despite recent positive data, citing uncertainties around Phase 3 ...

Hormone balance plays a role in maintaining bone density and strength. Progesterone aids in bone formation by supporting osteoblast (bone-building) activity, while estriol helps regulate the uptake of ...

Growth, bone density, histology and fracture number are important outcome parameters, but are not simple to measure accurately and reproducibly in children with severe OI. For example, using ...