UroToday4d
Single-cell RNA sequencing and spatial transcriptomics of bladder Ewing sarcoma.
Bladder Ewing sarcoma/primitive neuroectodermal tumor (bladder ES/PNET) is a rare and highly malignant tumor associated with a poor prognosis, yet its underlying mechanisms remain poorly understood.
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Trends and Outcomes in Sarcomatoid Renal Cell Carcinoma: Analysis of the National Cancer Data Base.
Our aim was to determine the clinical characteristics, temporal trends, and survival outcomes for sarcomatoid-dedifferentiated renal cell carcinoma (sRCC), as sRCC has historically had poor prognosis ...
UroToday4d
PIRADS 3 MRI lesions: are biopsies still necessary?
A significant proportion of newly diagnosed prostate cancer (PCa) cases are slow growing with a low risk of metastatic progression. There is a lack of data concerning the optimal biopsy regimen for ...
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Repurposing of Metformin to Improve Survival Outcomes in Patients With Upper Tract Urothelial Carcinoma.
Upper tract urothelial carcinoma (UTUC) presents a higher incidence rate in Taiwan compared to Western societies. The aim of this study is to investigate the potential of metformin in improving ...
UroToday5d
Germline Genetic Testing for Prostate Cancer: Ordering Trends in the Era of Expanded Hereditary Cancer Screening Recommendations - Beyond the Abstract
Prostate cancer is seeing an evolution in personalized precision treatment due in large part to germline genetic testing (GGT) and associated novel therapies such as PARP inhibitors. With the ...
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Current Status of Sequential Treatment for Castration-resistant Prostate Cancer: A Retrospective Analysis.
Although multiple treatments are available for metastatic castration-resistant prostate cancer, data to determine the optimal treatment sequence are limited. This study aimed to investigate the ...
UroToday4d
Comprehensive genomic characterization of early-stage bladder cancer.
Understanding the molecular landscape of nonmuscle-invasive bladder cancer (NMIBC) is essential to improve risk assessment and treatment regimens. We performed a comprehensive genomic analysis of ...
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Investigating the prognostic utility of GSTP1 promoter methylation in prostate cancer.
We aim to determine the prognostic significance of glutathione S-transferase Pi 1 DNA methylation (mGSTP1) in two independent prostate cancer cohorts with long-term clinical follow-up data. We first ...
UroToday4d
Pelvic regional control with 25Gy in 5 fractions in SBRT for high risk prostate cancer: Pooled prospective outcomes from the SHARP consortium.
To evaluate the efficacy of 25Gy/5# prophylactic pelvic nodal irradiation for regional control during stereotactic radiotherapy (SBRT) for high risk prostate cancer. The multinational XXXX consortium ...
UroToday5d
The Prognostic Role of HPV or p16INK4a Status in Penile Squamous Cell Carcinoma: A Meta-Analysis.
HPV infection is implicated in approximately half of global penile squamous cell carcinoma (PSCC) cases. Previous studies on HPV DNA and p16INK4a status in PSCC have yielded inconclusive prognostic ...
UroToday5d
Selective treatment de-escalation in advanced prostate cancer: have we come full circle?
Compelling evidence has solidified the notion of early treatment intensification in managing patients with metastatic hormone-sensitive prostate cancer (mHSPC). Landmark trials have provided Level 1 ...
UroToday5d
Predicting Response to Bipolar Androgen Therapy (BAT) - A Blood-Based Biomarker Approach
Alicia Morgans interviews Samuel Denmeade about the TRANSFORMER trial and Bipolar Androgen Therapy (BAT) for prostate cancer. Dr. Denmeade explains that the trial, involving 200 patients, compared ...